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While use throughout pregnancy might hurt the child, not utilizing it in methemoglobinemia is probably going more dangerous. Isobutyl nitrite is thought to cause methemoglobinemia. As a medicine, it’s primarily used to deal with methemoglobinemia by changing/chemically decreasing the ferric iron in hemoglobin to ferrous iron. Another use of methylene blue is to treat ifosfamide neurotoxicity. The dosing of methylene blue for therapy of ifosfamide neurotoxicity varies, relying upon its use concurrently as an adjuvant in ifosfamide infusion, versus its use to reverse psychiatric signs that manifest after completion of an ifosfamide infusion.
Prophylactic administration of methylene blue the day before initiation of ifosfamide, and 3 times each day throughout ifosfamide chemotherapy has been really helpful to decrease the prevalence of ifosfamide neurotoxicity. It has beforehand been used for treating cyanide poisoning and urinary tract infections, however this use is no longer beneficial. Methylene blue can also be very efficient when used as part of a «medicated fish bath» for therapy of ammonia, nitrite, and cyanide poisoning as well as Vapes for Sale topical and internal remedy of injured or sick fish as a «first response».